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When it comes to medical procedural dramas, ER walked so your favorite show can run.
The hit show, which premiered on NBC in 1994, followed a group of healthcare workers in the fictional County General Hospital as they tried to find the balance between their demanding jobs and equally chaotic personal lives.
The medical drama featured up-and-comers who would later become some of the world's biggest stars — including George Clooney, Julianna Margulies, Noah Wyle, Eriq La Salle and more, who all went on to have huge careers after the show ended its 15-season run.
Below, see what the main cast of season 1 of ER has been up to since the show wrapped in 2009.
George Clooney as Doug Ross
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Sven Arnstein/NBCU Photo Bank/NBCUniversal via Getty; Bruce Glikas/WireImage
On his way to becoming a movie star, George Clooney brought tons of charisma (and a very famous Caesar haircut) to the role of Dr. Doug Ross on ER. Following his five-season stint on the show, he went on to star in blockbuster movies such as From Dusk Till Dawn, O Brother, Where Art Thou?, Ides of March, the Oceans franchise, and many more films.
Though he spent most of his career as a highly sought-after bachelor, Clooney found love with barrister and human rights advocate Amal Alamuddin, whom he married in Italy in 2014. The two welcomed twins Alexander and Ella on June 6, 2017.
Eriq La Salle
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Years before Eriq La Salle's Peter Benton was running things on ER, the actor was making audiences laugh with his role as the oh-so-suave "Prince of Soul Glo," Daryl Jenks in Coming to America and had credits in movies and TV shows such as A Different World, Quantum Leap, The Human Factor and more.
Following his eight-season stint on the medical drama, La Salle continued to act, lending his talents to 24, How to Make It in America and Logan, with his latest credit in 2024's On Call.
Anthony Edwards as Mark Green
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Making sure that everything ran smoothly and that the troops were in line was Mark Greene, played by Anthony Edwards. Prior to landing the role, Edwards appeared in It Take Two, Northern Exposure, Don't Go Breaking My Heart and other notable works.
Like La Salle, Edwards was a fixture on the show for the first eight seasons before leaving to spend more time with his family. Though his character was killed off the show, he came back in a flashback sequence in season 15.
Edwards married makeup artist Jeanine Lobell in 1994; the couple welcomed four children together before divorcing in 2015. The actor found love again with Mare Winningham, whom he had previously worked with on ER and remained friends with through the years, growing closer during the COVID-19 pandemic in 2020. They eloped in 2021 and have been living happily ever after since.
Noah Wyle as John Carter
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Noah Wyle won the hearts of America playing baby-faced Dr. John Carter for 11 seasons. Over the years, the actor continued to forge a career in Hollywood, snagging roles in Falling Skies, Enough, The Librarians, The Californians and many more.
Thirty years after the premiere of ER, Wyle is back in the emergency room, playing Dr. Michael "Robby" Robinavitch in the critically-acclaimed Max series The Pitt.
Offscreen, Wyle is a dedicated family man. The actor has been married to wife Sara since 2014. The two welcomed daughter Frances a year later; she joined her older siblings Owen and Auden, whom Noah shares with his ex-wife Tracy Warbin.
Julianna Margulies as Carol Hathaway
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Julianna Margulies' portrayal of troubled registered nurse Carol Hathaway was so poignant, she won an Emmy in the show's first season. And her star only continued to rise.
Following her six seasons on the show, Margulies snagged roles in The Sopranos, Canterbury's Laws, Snakes on a Plane, and more, before she landed the lead role of Alicia Florrick in The Good Wife, for which she won an additional two Emmys.
Margulies has been married to lawyer Keith Lieberthal since 2007. The two share a son named Kieran Lindsay Lieberthal, whom they welcomed on Jan. 17, 2008.
William H. Macy as David Morgenstern
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NBC/Courtesy Everett; Chelsea Lauren/Shutterstock
Decades before he was causing havoc as Frank Gallagher on Shameless, William H. Macy was saving lives as chief of surgery Dr. David Morgenstern on ER. In the years between ER and Shameless, he appeared in The Maiden Heist, The Lincoln Lawyer, Versailles, Marmaduke and several other projects.
The two-time Emmy winner has been married to wife Felicity Huffman since 1997. They welcomed their eldest daughter, Sophia, in 2000 and their youngest Georgia joined the family in 2002.
Sherry Stringfield as Susan Lewis
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By the time Sherry Stringfield landed the role of Susan Lewis on ER, she had a well-established career. The actress had previously played Blake Thorpe in CBS' Guiding Light for three years. She also landed a small role in NYPD Blue before finally making her way to Cook County Hospital.
Following her time on the show, Stringfield has appeared in Tell Me You Love Me, The Stepfather, Under the Dome and more. Her most recent credit was in Criminal Minds: Beyond Borders, on which she played Karen Garrett from 2016 to 2017.
Stringfield has two children, Milo and Phoebe, whom she shares with ex-husband Larry Joseph.
Yvette Freeman as Haleh Adams
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Playing nurse Haleh Adams was Yvette Freeman, who portrayed the recurring character for the entirety of the show's 15-season run.
In the years since, Freeman has appeared in Days of Our Lives, The Bold and the Beautiful, Orange Is the New Black, A Black Lady Sketch Show and more.
According to IMDB, she's been married to Lanny Hartley since 1996.
Emily Wagner as Doris Pickman
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Like Freeman, Emily Wagner played the role of Doris Pickman for all of ER's 15 seasons.
Over the years, she's added to her resume with appearances in Judging Amy, Jack & Jill, Criminal Minds, Mr. Woodcock and more.
Deezer D as Malik McGrath
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Keeping the good vibes going amid all the chaos was licensed practical nurse Malik McGrath, who was played by the late Dearon Thompson, most commonly known as Deezer D.
Before his death at age 55 in 2021, the actor also made appearances in Romy and Michele's High School Reunion, Bringing Down the House, In the Mix and more.
Abraham Benrubi as Jerry Markovic
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Manning the phones and making sure the medical staff was updated with news of patients and then some, was County General Hospital's desk clerk Jerry Markovic, played by Abraham Benrubi.
The actor has been working steadily since the late '80s, when he played a bodyguard in Living Dolls. You've also seen Benrubi in Blossom, Parker Lewis Can't Lose, Sleepwalkers, Buffy the Vampire Slayer, Criminal Minds, Men in Trees and plenty more notable works.